Second-half goals from Mario Lemina and Matt Doherty secured victory for the hosts, who recorded successive league wins against Chelsea for the first time in nearly half a century.
Substitute Christopher Nkunku headed home in injury time on his Premier League debut but it was not enough to salvage a point for the Blues, who lost a fourth consecutive away league game for the first time since December 2000.
This was another day when Chelsea's failings in attack came back to haunt them. They have now have failed to convert 36 big chances in the league this season - the most of any team.
Pochettino said: "We feel very disappointed because I think we deserve much more. This competition wounds you when you are not clinical enough.
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